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Prodrug BMP-7 attenuates pulmonary fibrosis through downregulation of bone marrow derived ApoE+ alveolar macrophage
2024-09-24
respiratory medicine
Title + abstract only
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BackgroundBone morphogenetic protein-7 (BMP-7) antagonises transforming growth factor-{beta} (TGF-{beta}). This study investigated the ability of a prodrug BMP-7, designed as micelle nanoparticles for nasal inhalation, to ameliorate pulmonary fibrosis in a bleomycin (BLM)-induced murine model. Materials and MethodsFluorescently labelled BMP-7 was delivered to murine lungs via nasal inhalation. Thirty-eight C57BL/6J mice were divided into three groups: control, BLM and BLM with prodrug BMP-7. We...
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