Innate immune epigenomic landscape following controlled human influenza virus infection
Thistlethwaite, W.; Vangeti, S.; Cheng, W.-S.; Agarwal, P.; Cappuccio, A.; Wang, W.; Wei, B.; Myers, R.; Rubenstein, A. B.; Chawla, D.; Hariharan, M.; McClain, M. T.; Burke, T. W.; Kleinstein, S. H.; Ecker, J. R.; Woods, C. W.; Greenleaf, W. J.; Chen, X.; Ramos, I.; Zaslavsky, E.; Evans, T. G.; Troyanskaya, O. G.; Sealfon, S. C.
Show abstract
Viral infections can induce changes in innate immunity that persist after virus clearance. Here, we used blood samples from a human influenza H3N2 challenge study to perform comprehensive multi-omic analyses. We detected remodeling of immune programs in innate immune cells after resolution of the infection that was proportional in magnitude to the level of prior viral load. We found changes associated with suppressed inflammation including decreased cytokine and AP-1 gene expression as well as decreased accessibility at AP-1 targets and interleukin-related gene promoter regions. We also found decreased histone deacetylase gene expression, increased MAP kinase gene expression, and increased accessibility at interferon-related gene promoter regions. Genes involved in inflammation and epigenetic-remodeling showed modulation of gene-chromatin site regulatory circuit activity. These results reveal a coordinated rewiring of the epigenetic landscape in innate immune cells induced by mild influenza virus infection.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium 95%
- Single-cell Transcriptome of Bronchoalveolar Lavage Fluid Reveals Dynamic Change of Macrophages During SARS-CoV-2 Infection in Ferrets 94%
- Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity 94%
Similar papers in this journal
- Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans 95%
- The Hypoxia-regulated Ectonucleotidase CD73 is a Host Determinant of HIV Latency 94%
- Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral Infection 94%
Similar papers in this journal
Similar papers in this journal
- Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type 1 interferon responses and distinct from other acute respiratory viruses 96%
- Rewired type I IFN signaling is linked to age-dependent differences in COVID-19 95%
- RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.