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Mendelian randomization suggests a causal link between glycemic traits and thoracic aortic structures and diseases

2024-09-19 genetic and genomic medicine Title + abstract only
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ImportanceType 2 diabetes mellitus (T2DM) and elevated glucose levels have been inversely associated with aortic aneurysms. However, the causality of this relationship remains uncertain. Additionally, there is a lack of studies investigating the association between glycemic traits and imaging-based thoracic aortic phenotypes. ObjectiveWe investigated whether T2DM and glycemic measures (fasting glucose (FG), fasting insulin (FI), glycated hemoglobin (HbA1c), and 2-hour post-load glucose (2hPG)) ...

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