Fibroblasts Regulate the Transformation Potential of Human Papillomavirus-positive Keratinocytes
James, C. D.; Lewis, R. L.; Witt, A. J.; Carter, C.; Rais, N. M.; Wang, X.; Bristol, M. L.
Show abstract
Persistent human papillomavirus (HPV) infection is necessary but insufficient for viral oncogenesis. Additional contributing co-factors, such as immune evasion and viral integration have been implicated in HPV-induced cancer progression. It is widely accepted that HPV+ keratinocytes require co-culture with fibroblasts to maintain viral episome expression, yet the exact mechanisms for this have yet to be elucidated. Here we present comprehensive RNA sequencing and proteomic analysis demonstrating that fibroblasts not only support the viral life cycle, but reduce HPV+ keratinocyte transformation. Our co-culture models offer novel insights into HPV-related transformation mechanisms. HighlightsO_LIFibroblasts support HPV RNA expression and episomal maintenance in HPV+ keratinocytes C_LIO_LIFibroblasts reduce EMT related expression in HPV+ keratinocytes C_LIO_LIFibroblasts promote EMT related expression in E6E7+ keratinocytes C_LI
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The splicing factor kinase, SR protein kinase 1 (SRPK1) is essential for late events in the human papillomavirus life cycle. 97%
- Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics 95%
- Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling 94%
Similar papers in this journal
- Understanding the impact of high-risk human papillomavirus on oropharyngeal squamous cell carcinomas in Taiwan: A retrospective cohort study 93%
- Glyoxalase 1: emerging biomarker and therapeutic target in cervical cancer progression 93%
- Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA.1 infection of K18-hACE2 mice 93%
Similar papers in this journal
- Systematic analysis of IL-1 cytokine signaling suppression by high-risk HPV oncoproteins 94%
- Fibroblast Stromal Support Model for Predicting Human Papillomavirus-Associated Cancer Drug Responses. 94%
- Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycle. 94%
Similar papers in this journal
- FOXO1 mitigates the SMAD3/FOXL2C134W Transcriptomic Effect in a Model of Human Adult Granulosa Cell Tumor 92%
- Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer 91%
- Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse 90%
Similar papers in this journal
- Investigating the potential role of capsaicin in facilitating the spread of coxsackievirus B3 via extracellular vesicles 92%
- Pro-apoptotic and anti-invasive properties underscore the tumor suppressing impact of myoglobin on subset of human breast cancer cells 92%
- Evaluating HIV Infectivity and Virion Maturation Across Varied Producer Cells with a Novel FRET-Based Detection and Quantification Assay 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.