Megabouts: a flexible pipeline for zebrafish locomotion analysis
Jouary, A.; Laborde, A.; Silva, P. T.; Mata, J. M.; Marques, J. C.; Collins, E.; Peterson, R. T.; Machens, C. K.; Orger, M. B.
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Accurate quantification of animal behavior is crucial for advancing neuroscience and for defining reliable physiological markers. We introduce Megabouts (megabouts.ai), a software package standardizing zebrafish larvae locomotion analysis across experimental setups. Its flexibility, achieved with a Transformer neural network, allows the classification of actions regardless of tracking methods or frame rates. We demonstrate Megabouts ability to quantify sensorimotor transformations and enhance sensitivity to drug-induced phenotypes through high-throughput, high-resolution behavioral analysis.
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