Electromagnetic waves destabilize the SARS-CoV-2 Spike protein and reduce SARS-CoV-2 Virus-Like Particle (SC2-VLP) infectivity
Granatir, S.; Acosta, F. M.; Pantoja, C.; Tailor, J.; Fuori, A.; Dower, B.; Marr, H.; Ramirez, P. W.
10.1101/2024.09.11.612487 bioRxivShow abstract
Infection and transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to pose a global public health concern. Using electromagnetic waves represents an alternative strategy to inactivate pathogenic viruses such as SARS-CoV-2 and reduce overall transmission. However, whether electromagnetic waves reduce SARS-CoV-2 infectivity is unclear. Here, we adapted a coplanar waveguide (CPW) to identify electromagnetic waves that could neutralize SARS-CoV-2 virus-like particles (SC2-VLPs). Treatment of SC2-VLPs, particularly at frequencies between 2.5-3.5 GHz at an electric field of 400 V/m for 2 minutes, reduced infectivity. Exposure to a frequency of 3.1 GHz decreased the binding of SC2-VLPs to antibodies directed against the Spike S1 subunit receptor binding domain (RBD). These results suggest that electromagnetic waves alter the conformation of Spike, thereby reducing viral attachment to host cell receptors. Overall, this data provides proof-of-concept in using electromagnetic waves for sanitation and prevention efforts to curb the transmission of SARS-CoV-2 and potentially other pathogenic enveloped viruses.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The virucidal effects of 405 nm visible light on SARS-CoV-2 and influenza A virus 94%
- Scalable, effective, and rapid decontamination of SARS-CoV-2 contaminated N95 respirators using germicidal ultra-violet C (UVC) irradiation device 93%
- UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication 93%
Similar papers in this journal
- Long-Term In Vivo Biocompatibility of Single-Walled Carbon Nanotubes 92%
- THz irradiation inhibits cell division by affecting actin dynamics 92%
- From “don, doff, and discard” to “don, doff, and decontaminate” – determination of filtering facepiece respirator and surgical mask integrity and inactivation of a SARS-CoV-2 surrogate and a small non-enveloped virus following multiple-cycles of vaporised hydrogen peroxide, ultraviolet germicidal irradiation, and dry heat decontamination 92%
Similar papers in this journal
- Humidity and deposition solution play a critical role in virus inactivation by heat treatment on N95 respirators 91%
- Liquid chalk is an antiseptic against SARS-CoV-2 and influenza A respiratory viruses 90%
- Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Virologic Confirmation of Suitability for Re-Use During the COVID-19 Pandemic 90%
Similar papers in this journal
- In Vitro Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2 93%
- Disinfection of SARS-CoV-2 contaminated surfaces of personal items with UVC-LED disinfection boxes 92%
- Effects of inactivation method on SARS-CoV-2 virion proteins and structure 92%
Similar papers in this journal
- Mechanical Dissociation of Tissues for Single Cell Analysis Using a Simple Motorized Device 91%
- Application of monolayer graphene to cryo-electron microscopy grids for high-resolution structure determination 91%
- Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions between Non-Coding RNAs in Cancer Cells 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.