The Greenland shark (Somniosus microcephalus) genome provides insights into extremelongevity
Sahm, A.; Cherkasov, A.; Liu, H.; Voronov, D.; Siniuk, K.; Schwarz, R.; Ohlenschlaeger, O.; Foerste, S.; Bens, M.; Groth, M.; Goerlich, I.; Paturej, S.; Klages, S.; Braendl, B.; Olsen, J.; Bushnell, P.; Poulsen, A. B.; Ferrando, S.; Garibaldi, F.; Drago, D. L.; Tozzini, E. T.; Mueller, F.-J.; Fischer, M.; Kretzmer, H.; Domenici, P.; Steffensen, J. F.; Cellerino, A.; Hoffmann, S.
Show abstract
The Greenland shark (Somniosus microcephalus) is the longest-lived vertebrate known, with an estimated lifespan of [~] 400 years. Here, we present a chromosome-level assembly of the 6.45 Gb Greenland shark, rendering it one of the largest non-tetrapod genomes sequenced so far. Expansion of the genome is mostly accounted for by a substantial expansion of transposable elements. Using public shark genomes as a comparison, we found that genes specifically duplicated in the Greenland shark form a functionally connected network enriched for DNA repair function. Furthermore, we identified a unique insertion in the conserved C-terminal region of the key tumor suppressor p53. We also provide a public browser to explore its genome.
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