Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants
Hernandez, V. S. d. M.; Garcia, M. M. N.; Clavel, M.; Papareddy, R. K.; Andreev, V. I.; Gao, P.; De la Concepcion, J. C.; Mathur, V.; Picchianti, L.; Grujic, N.; Kobylinska, R.; Abdrakhmanov, A.; Duverge, H.; Anand, G.; Leibrock, N.; Bianchi, A.; Crawford, T.; Argiro, L.; Mohseni, A.; Leon, M. G.; Matuszkiewickz, M.; Raffeiner, M.; Wun, C.-L.; Kanne, J. V.; Meinhart, A.; Roitinger, E.; Baurle, I.; Kang, B.-H.; Petersen, M.; Ustun, S.; Kulathu, Y.; Clausen, T.; Ramundo, S.; Dagdas, Y.
Show abstract
Selective autophagy is a fundamental protein quality control pathway that safeguards proteostasis by degrading damaged or surplus cellular components, particularly under stress. This process is orchestrated by selective autophagy receptors (SARs) that direct specific cargo for degradation. While significant strides have been made in understanding the molecular framework of selective autophagy, the diversity of SAR repertoires across species remain largely unexplored. Through a comparative interactome analysis across five model organisms, we identified a suite of conserved and lineage-specific SAR candidates. Among these, we validated CESAR as a conserved SAR critical for proteostasis under heat stress. CESAR specifically facilitates the degradation of hydrophobic, ubiquitinated protein aggregates and is indispensable for heat stress tolerance. Our study offers a rich resource for SAR discovery and positions CESAR as a pivotal regulator of proteostasis, with broad implications for improving stress resilience in plants.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- The landscape of cellular clearance systems across human tissues and cell types is shaped by tissue-specific proteome needs 94%
- Lysosomal degradation ensures accurate chromosomal segregation to prevent genomic instability 94%
- Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis 93%
Similar papers in this journal
- The Proxitome of Arabidopsis Processing Bodies Reveals a Condensate-Membrane Interface Instructing Actin-Driven Directional Growth 96%
- Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy 96%
- ROS production by localized SCHENGEN receptor module drives lignification at subcellular precision 96%
Similar papers in this journal
- Dynamic mapping of proteome trafficking within and between living cells by TransitID 96%
- FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis 96%
- Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.