Single-cell immune survey identifies a novel pathogenic role for T cells in anti-NMDA receptor encephalitis
Kwok, A. J.; Soleimani, B.; Sun, B.; Fower, A.; Makuch, M.; Johnson, T.; Knight, J. C.; Ko, H.; Lennox, B.; Irani, S. R.; Handunnetthi, L.
Show abstract
We performed single-cell RNA and immune receptor repertoire sequencing of an N-methyl-D-aspartate receptor encephalitis (NMDARE) patient in relapse and remission states, as well as an autoimmune psychosis (AP) patient with anti-NMDAR antibodies. We leveraged publicly available cerebrospinal fluid (CSF) single-cell sequencing data from other neurological disorders to contextualise our findings. Results highlight a key role for T-cells in NMDARE pathogenesis with clonal expansion of both cytotoxic CD4+ and CD8+ effector memory cells in CSF. We further identified interferon responsive B-cells in the CSF during the acute phase of NMDARE and a higher proportion of mononuclear phagocytes in the CSF of AP. Collectively, our work sheds light into the immunobiology of anti-NMDAR antibody-mediated disease.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Senescent-like microglia limit remyelination through the senescence associated secretory phenotype 95%
- Microenvironment Impacts the Molecular Architecture and Interactivity of Resident Cells in Marmoset Brain 95%
- Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection 94%
Similar papers in this journal
Similar papers in this journal
- Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glia responses 96%
- Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia 93%
- The Alzheimers Disease Risk Genes MS4A4A And MS4A6A Cooperate to Negatively Regulate Trem2 and Microglia states 92%
Similar papers in this journal
- Augmentation of a neuroprotective myeloid state by hematopoietic cell transplantation 95%
- Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis 95%
- Cell-type specific cis-eQTLs in eight brain cell-types identifies novel risk genes for human brain disorders 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.