Back

Children and Adolescent Patients with the Variants in the ATP1A3-encoded Sodium-Potassium ATPase Alpha-3 Subunit Demonstrate Impaired QT Response to Bradycardia and Predisposition to Sinus Node Dysfunction

2024-09-01 cardiovascular medicine Title + abstract only
View on medRxiv
Show abstract

BackgroundAlternating hemiplegia of childhood (AHC) is a rare disorder with both neurologic and cardiac manifestations. The ATP1A3-D801N variant is associated with a pathologically short QT interval and risk of ventricular arrhythmia following bradycardia; however, the mechanism of this remains unknown. We investigated the relationship between heart rate (HR), QT, and QTc, hypothesizing that individuals with ATP1A3-D801N have abnormal, impaired shortening of QT and QTc at lower HR leading to arr...

Predicted journal destinations

1
Circulation: Genomic and Precision Medicine
30 training papers
#1 24.7%
2
Circulation
37 training papers
Top 0.3% 13.1%
3
Journal of the American Heart Association
92 training papers
Top 4% 10.0%
4
Heart Rhythm
16 training papers
Top 0.4% 6.6%
5
Scientific Reports
701 training papers
Top 35% 6.6%
6
Frontiers in Cardiovascular Medicine
33 training papers
Top 4% 5.6%
7
The American Journal of Cardiology
15 training papers
Top 2% 3.5%
8
Open Heart
18 training papers
Top 3% 3.1%
9
European Heart Journal - Digital Health
15 training papers
Top 1% 2.2%
10
PLOS ONE
1737 training papers
Top 91% 2.2%
11
Hypertension
20 training papers
Top 2% 2.2%
12
Journal of Clinical Medicine
77 training papers
Top 12% 1.5%
13
eLife
262 training papers
Top 30% 1.5%
14
Atherosclerosis
16 training papers
Top 4% 1.3%
15
Nature Communications
483 training papers
Top 52% 1.1%
16
Nature Genetics
72 training papers
Top 9% 1.1%
17
Frontiers in Physiology
18 training papers
Top 2% 1.1%
18
BMJ Open
553 training papers
Top 61% 1.1%
19
Frontiers in Neurology
74 training papers
Top 13% 0.8%
20
BMC Medicine
155 training papers
Top 31% 0.8%
21
PLOS Medicine
95 training papers
Top 20% 0.8%
22
Nature Medicine
88 training papers
Top 24% 0.5%
23
Genome Medicine
56 training papers
Top 9% 0.5%