GlycoRNA-L and glycoRNA-S mediate human monocyte adhesion via binding to Siglec-5
Fu, M.; Qian, Y.; Huang, E.; Schwartz, Z.; Tai, H.; Tillock, K.; Lei, T.
Show abstract
It was recently reported that RNAs can be glycosylated, and a majority of such glycosylated RNAs (referred to as glycoRNAs) are located on the outer cell surface. We here reported that there are two forms of glycoRNAs, named as glycoRNA-L and glycoRNA-S, robustly expressed in human monocytes. Both of glycoRNA-L and glycoRNA-S contributed to the interaction of human monocytes and endothelial cells via directly binding to Siglec-5. GlycoRNA-L predominantly expressed in most of tissues and cell lines. GlycoRNA-S only expressed in some cell lines and tissues. Siglec-5 preferentially binds to glycoRNA-L than glycoRNA-S. The composition of glycan chains in glycoRNA-L and glycoRNA-S is different. GlycoRNA-L contains more sialic acid, whereas glycoRNA-S contains more GlcNAc. Together, these results demonstrate that two forms of glycoRNAs exist, which may play significant role in controlling the interaction of human monocytes and endothelial cells and contribute to the pathogenesis of inflammatory diseases.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- An arms race between 5'ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish 94%
- Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables tunable self-amplifying RNA expression with reduced immunotoxicity 94%
- The lnc-FANCI-2 intrinsically restricts RAS signaling in HPV16-infected cervical cancer 94%
Similar papers in this journal
Similar papers in this journal
- Genome-scale CRISPR-Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infection. 94%
- Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalization 94%
- Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.