Cellular and molecular networks of intercellular signaling in bone marrow hematopoiesis
Thomas, Z.; Wang, B.; Boohar, W.; Vergel, M.; Eerdeng, J.; Shon, D.; Elowitz, M. B.; Lu, R.
Show abstract
Hematopoietic stem and progenitor cells (HSPCs) rely on intercellular signaling to maintain and adjust their production of blood and immune cells. This process occurs in the semi-fluidic bone marrow, hosting dozens of cell types that constantly migrate and interact. To elucidate the dynamic network of cell-cell interaction and signaling transduction underlying hematopoiesis, we developed an algorithm to measure Cell-cell Spatial Interaction Probability (CellSIP) by integrating data on ligand and receptor expression, cell type abundance, and cellular spatial positioning. Using new and published mouse datasets, we validated CellSIP and uncovered signaling transductions indicating feedback mechanisms underlying hematopoiesis. Moreover, we identified significant correlations between signaling pathways across individual HSPCs at the same hematopoiesis stage. These pathway correlations illuminate the organization of cellular and signaling networks underlying hematopoiesis, revealing new regulators through their associations with established ones. The signaling quantification and correlation data are available through the Hematopoiesis Intercellular Signaling Explorer (HISE).
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