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Cell type and locus-specific epigenetic editing of memory expression

Coda, D. M.; WATT, L.; glauser, l.; Batiuk, M.; Burns, A.; Stahl, C.; Graeff, J.

2024-08-18 neuroscience
10.1101/2024.08.18.608454 bioRxiv
Show abstract

Epigenetic modifications parallel multiple memory processes, but evidence that the epigenetic makeup of a single site can guide learnt behaviors has so far been lacking. Here, we developed CRISPR-based epigenetic editing tools to address this question in a cell type-specific, locus-restricted and temporally controllable manner in the adult mouse brain. Focusing on learning-induced neuronal populations, we provide a proof-of-principle that site-specific epigenetic dynamics are causally implicated in memory expression.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.