RIPK4 driven by TP53 mutations promotes resistance to redox stress of CRC by phosphorylating MTHFD1
Yu, L.; Zhou, S.; Xu, Y.; Zhang, Z.; Cheng, X.; Zhou, C.; Li, W.; He, J.; Ou, Q.; Qin, J.; Fang, Y.-J.; Peng, J.; Lin, J.-Z.; Lin, B.; Hou, Z.; Pan, Z.
Show abstract
This study investigates advanced colorectal cancer (CRC), focusing on its tendency for distant metastasis and chemotherapy resistance. It highlights the importance of PANoptosis, a cell death pathway, and the role of the Receptor-interacting serine/threonine-protein kinase (RIPK) family in tumor progression. RIPK4s tissue-specific functions in cancer cell behavior are emphasized, including its influence on invasion, migration, and oxidative stress resistance. The study reveals the critical balance of reactive oxygen species (ROS) in cancer cells, linked to antioxidant defenses and NADPH production for survival. A key finding is the connection between TP53 mutations in CRC and increased RIPK4 expression, which enhances MTHFD1 phosphorylation, boosts NADPH production, reduces ROS, and promotes resistance to PANoptosis, leading to metastasis. The research identifies the molecular basis of CRC metastasis, showing how RIPK4 regulates MTHFD1 to resist PANoptosis, offering new therapeutic targets for metastatic CRC and potential improvements in patient outcomes.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer 96%
- S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism 96%
- Bestrophin-4 relays Hes4 and interacts with Twist1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells 96%
Similar papers in this journal
- Branched chain amino acid aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells 97%
- RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence 95%
- The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers 95%
Similar papers in this journal
- Characterization of the Mechanisms Underlying Sulfasalazine-Induced Ferroptotic Cell Death: Role of Protein Disulfide Isomerase-Mediated NOS Activation and NO Accumulation 93%
- Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease 93%
- M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction 92%
Similar papers in this journal
- The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage. 94%
- Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer 94%
- TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis 94%
Similar papers in this journal
- Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression ofPAK3 via miRNA regulation 96%
- H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis 95%
- Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.