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Dynamic adaptation to novelty in the brain is related to arousal and intelligence

Tanner, J. C.; Faskowitz, J.; Kennedy, D. P.; Betzel, R.

2024-08-06 neuroscience
10.1101/2024.08.02.606380 bioRxiv
Show abstract

How does the human brain respond to novelty? Here, we address this question using fMRI data wherein human participants watch the same movie scene four times. On the first viewing, this movie scene is novel, and on later viewings it is not. We find that brain activity is lower-dimensional in response to novelty. At a finer scale, we find that this reduction in the dimensionality of brain activity is the result of increased coupling in specific brain systems, most specifically within and between the control and dorsal attention systems. Additionally, we found that novelty induced an increase in between-subject synchronization of brain activity in the same brain systems. We also find evidence that adaptation to novelty, herein operationalized as the difference between baseline coupling and novelty-response coupling, is related to fluid intelligence. Finally, using separately collected out-of-sample data, we find that the above results may be linked to psychological arousal.

Published in Cerebral Cortex (predicted rank #2) · training set

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