Individualized Hybrid Electroconvulsive Therapy (i-HECT) Shows Rapid Anti-Depressant Effect and Improved Cognition in Young Patients with Depression
Zhang, J.-y.; Zeng, L.; Li, J.; Chen, M.-m.; Xu, S.-x.; Tan, B.; Xie, X.-h.
Show abstract
BackgroundFor young patients with depression, electroconvulsive therapy (ECT) is highly effective but causes acute cognitive side effects. We designed a new i-HECT therapy combines ECT with low-charge electrotherapy (LCE) and individual symptom monitoring to reduce cognitive impairments. Methodsi-HECT comprised two treatments: ECT and LCE. ECT utilized an energy set of 1.5 times the seizure threshold (ST), while LCE was set at 0.5 ST. The initial session employed ECT. Subsequent sessions involved ECT or LCE, depending on whether meeting the ECT-LCE transition criteria (MADRS total score < 22 or [≥] 50% reduction), assessed after each session. ResultsThe intention-to-treat analysis revealed an 80.4% response rate and a 58.7% remission rate (Hedges g = 3.29). Notably, both subjective and objective cognitive functions significantly improved post-i-HECT treatments and during the 3-month follow-up periods. ConclusionThe i-HECT protocol may provide a rapid antidepressant treatment option with cognitive benefits for young depression patients. HighlightsO_LIDesigned a novel but simple ECT protocol, i-HECT, for young depression patients. C_LIO_LIThe trial employed Simons optimal two-stage design with a high power of 0.95. C_LIO_LIThe i-HECT rapidly improved both depression symptoms and cognitive functions. C_LI
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation Associated With Major Depressive Disorder: Protocol for a Randomized Controlled Trial 95%
- Pharmacotherapy, drug-drug interactions and potentially inappropriate medication in depressive disorders 94%
- Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression: A protocol for a systematic review and meta-analysis 94%
Similar papers in this journal
- Oral Ketamine for the Treatment of Depression: A randomized controlled trial and meta-analysis 95%
- Electroconvulsive therapy effects on anhedonia and reward circuitry anatomy: a dimensional structural neuroimaging approach 93%
- Effects of bilateral sequential theta-burst stimulation on functional connectivity in treatment-resistant depression: first results 92%
Similar papers in this journal
- Development, validation and clinical utility of Short-term AdVerse-effects of Electroconvulsive therapy (SAVE) Checklist 95%
- Cost-effectiveness analysis comparing repetitive transcranial magnetic stimulation therapy with antidepressant treatment in patients with treatment-resistant depression in Japan 93%
- The recurrence of illness (ROI) index is a key factor in major depression that indicates increasing immune-linked neurotoxicity and vulnerability to suicidal behaviors. 92%
Similar papers in this journal
- The Project for Objective Measures Using Computational Psychiatry Technology (PROMPT): Rationale, Design, and Methodology 89%
- Plant Formulation ATRICOV 452 in Improving the Level of COVID-19 Specific Inflammatory Markers in Patients 89%
- Erroneous risks in pharmaceutical versus non-pharmaceutical interventions during data extraction in evidence synthesis practice: Study protocol for a randomized controlled trial 87%
Similar papers in this journal
- Unilateral and Bilateral Theta Burst Stimulation for Treatment-Resistant Depression: Follow up on a Naturalistic Observation Study 93%
- Estimating heterogeneity of treatment effect in psychiatric clinical trials 91%
- Bilateral Sequential Theta Burst Stimulation for Multiple-Therapy-ResistantDepression: a naturalistic observation study 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.