Natural Selection in a Synthetic Yeast Endosymbiont Promotes Stable Coexistence
Supekova, L.; Zhou, H.; Barcellos, I. H.; Nguyen, C.; Dik, D. A.; Schultz, P. G.
Show abstract
Bacteria engulfment by a higher order host is believed to be the beginning of an evolutionary process that ultimately formed mitochondria. In an effort to experimentally elucidate the early effects of natural selection on bacteria resident in a eukaryotic host, a synthetic endosymbiont model system has been exploited. Here we describe a reproducible series of mutations that were observed after Escherichia coli was passaged within Saccharomyces cerevisiae for >8 passages which led to enhanced coexistence of bacteria within the yeast. These naturally selected mutations, formed by gene acquisition of trans-posable elements in rcsC, cpxA, and idnK, result in both functional and non-functional protein products with phenotypic effects on the bacteria that promote endosymbiont stability.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Decoupling growth and production by removing the origin of replication from a bacterial chromosome 95%
- Impact of exogenous aminoacyl-tRNA synthetase and tRNA on temperature sensitivity in Escherichia coli 95%
- Improving the robustness of engineered bacteria to nutrient stress using programmed proteolysis 94%
Similar papers in this journal
- Diverse Protein Architectures and α-N-Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters 92%
- Biosynthesis of the azoxy compound azodyrecin from Streptomyces mirabilis P8-A2 92%
- Exploring metalloproteome remodeling in calprotectin-stressed Acinetobacter baumannii using chemoproteomics 92%
Similar papers in this journal
Similar papers in this journal
- Determinants of multiheme cytochrome extracellular electron transfer uncovered by systematic peptide insertion 94%
- α-carboxysome size is controlled by the disordered scaffold protein CsoS2 92%
- (R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase, a new PLP-dependent enzyme involved in bacterial phosphonate degradation 91%
Similar papers in this journal
- Gluconobacter oxydans Knockout Collection Finds Improved Rare Earth Element Extraction 95%
- Mutational meltdown of microbial altruists in Streptomyces coelicolor colonies 94%
- Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.