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Some statistical theory for interpreting reference distributions

2024-07-24 pathology Title + abstract only
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Reference distributions quantify the extremeness of clinical test results, typically relative to those of a healthy population. Intervals of these distributions are used in medical decision-making, but while there is much guidance for constructing them, the statistics of interpreting them for diagnosis have been less explored. Here we work directly in terms of the reference distribution, defining it as the likelihood in a posterior calculation of the probability of disease. We thereby identify a...

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