Nanoscale organization is changed in native, surface AMPARs by mouse brain region and tauopathy
Vaidya, R. M.; Zhang, J.; Nall, D.; Lee, Y.; Kim, E. C.; Ma, D.; Huang, F.; Nonaka, H.; Kiyonaka, S.; Hamachi, I.; Chung, H. J.; Selvin, P. R.
Show abstract
Synaptic AMPA receptors (AMPARs) on neuronal plasma membranes are correlated with learning and memory. Using a unique labeling and super-resolution imaging, we have visualized the nanoscale synaptic and extra-synaptic organization of native surface AMPARs for the first time in mouse brain slices as a function of brain region and tauopathy. We find that the fraction of surface AMPARs organized in synaptic clusters is two-times smaller in the hippocampus compared to the motor and somatosensory cortex. In 6 months old PS19 model of tauopathy, synaptic and extrasynaptic distributions are disrupted in the hippocampus but not in the cortex. Thus, this optimized super-resolution imaging tool allows us to observe synaptic deterioration at the onset of tauopathy before apparent neurodegeneration.
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