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Prevalence of bias attributable to composite outcome in clinical trials: a systematic review

2024-07-18 epidemiology Title + abstract only
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ObjectiveTo investigate the prevalence of bias attributable to composite outcome (BACO) in clinical trials. Study design and settingWe searched PubMed for randomized clinical trials where the primary outcome was a binary composite that included all-cause mortality among its components from January 1, 2019, to December 31, 2020. For each trial, the BACO index was calculated to assess the correspondence between effects on the composite outcome and that on mortality. This systematic review was reg...

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