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Catecholaminergic modulation of large-scale network dynamics is tied to the reconfiguration of corticostriatal connectivity

2024-07-15 psychiatry and clinical psychology Title + abstract only
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Large-scale brain network function is critical for healthy cognition, yet links between such network function, neurochemistry, and smaller-scale neurocircuitry are unclear. Here, we evaluated 59 healthy individuals using resting-state fMRI to determine how network-level temporal dynamics were impacted by two well-characterized pharmacotherapies targeting catecholamines: methylphenidate (20mg) and haloperidol (2mg). Network dynamic changes were tested for links with drug-induced alterations in co...

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