Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses
Fang, Y.; Guan, Z.; Zhu, X.; Guan, Z.; Li, S.; Peng, K.
Show abstract
Apoptosis has been recognized as a suicidal host-defense programmed cell death pathway against invading pathogens. However, recent evidences showed that viruses can employ caspases to cleave and inactivate immune signaling molecules to facilitate infection. Whether caspases can promote anti-viral immune responses is currently unknown. Here, we demonstrated that the NSs protein of RVFV triggers activation of apoptotic caspases, which cleave the mitochondrial fission factor DRP1 resulting in mitochondrial elongation. Elongated mitochondria promote MAVS aggregation leading to enhanced anti-viral immunity. Apoptotic caspases, including caspase-3, -6, -7 and -8, cleave DRP1 at the motifs of D500FAD503 and/or AEAD556, suggesting that this cleavage event may occur during infection of different viruses. Indeed, infection of H1N1, SeV and HSV-1 all triggered apoptotic caspases activation to cleave DRP1 promoting anti-viral immune responses. Compared with wild-type DRP1, introduction of caspase-resistant DRP1 strongly attenuated immune responses triggered by virus infection. These results revealed a novel mechanism through which apoptotic caspases promote anti-viral immunity by regulating mitochondrial morphodynamics.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- RTN3 inhibits RIGI-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination 96%
- An arms race between 5'ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish 96%
- Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response 96%
Similar papers in this journal
- Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication 96%
- piR-bmo-796514 Facilitates the Proliferation of Exogenous DNA Virus (Baculovirus) by Targeting the Host E3 Ubiquitin Ligase RNF181 95%
- SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion 94%
Similar papers in this journal
- The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response 97%
- Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation 95%
- AGPAT1 is a novel Chikungunya virus receptor on human cells 95%
Similar papers in this journal
- The African Swine Fever Virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses 97%
- Caspase-dependent cleavage of DDX21 suppresses host innate immunity 97%
- The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release 95%
Similar papers in this journal
- Innate Immune sensing of Influenza A viral RNA through IFI16 promotes pyroptotic cell death 96%
- Activation of cGAS/STING pathway upon paramyxovirus infection 96%
- BK polyomavirus evades innate immune sensing by disrupting the mitochondrial network and membrane potential and by promoting mitophagy 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.