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An integrated multi-omics investigation of W-NK1, a cytokine-primed non-engineered natural killer cell therapy product
2024-07-10
hematology
Title + abstract only
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BackgroundNatural killer (NK) cells originate from bone marrow precursors and mediate effective anti-tumor responses. Clinical trials of cytokine-primed memory-like (ML) NK cells in acute myeloid leukemia (AML) have demonstrated activity without major toxicity, including graft-versus-host disease or cytokine release syndrome. However, broad application of non-expanded, non-engineered ML NK cells has been hindered by limited availability of NK cells from a single donor, thereby precluding aggress...
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