A discrete sarcomere model reveals internal unbinding dynamics and conditions for regularity of spontaneous oscillatory contractions
Warmington, B.; Bloomfield-Gadelha, H.; Rossiter, J.
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Using a discrete modelling approach for myosin systems we demonstrate how structural differences between single myosin filaments and sarcomeres allow for self similarity during sarcomeric spontaneous oscillatory contractions (SPOC). The form of our modelled SPOC recapitulates the subtleties of in vitro SPOCs more closely than prior modelling methods, suggesting we are capturing internal dynamics of the sarcomere that are either not generally considered or previously unknown. These results reinforce the value of discretely modelling molecular motor systems.
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