DWARF14 and KARRIKIN INSENSITIVE2 mediate signaling of the apocarotenoid zaxinone in Arabidopsis
Moreno Beltran, J. C.; Shahul Hameed, U. F.; Balakrishna, A.; Ablazov, A.; Liew, K. X.; Jamil, M.; Mi, J.; Alashoor, K.; de Saint Germain, A.; Arold, S. T.; Al-Babili, S.
Show abstract
The natural growth regulator zaxinone increases the levels of the phytohormones strigolactone (SL) and abscisic acid in Arabidopsis (Arabidopsis thaliana) via unknown mechanisms. We demonstrate that parts of the effects of zaxinone in Arabidopsis depend on the SL receptor DWARF14 (AtD14), the karrikin receptor KARRIKIN INSENSITIVE2 (AtKAI2), and the F-Box protein MORE AXILLARY BRANCHING2 (AtMAX2) that mediates the signaling of SLs and karrikins. Binding assays and co-crystallization revealed zaxinone as an additional ligand of AtD14 and an SL antagonist that interrupts the interaction of AtD14 with AtMAX2. Zaxinone also bound to AtKAI2. These findings unveil a perception mechanism for zaxinone in Arabidopsis and demonstrate the capability of AtD14 and AtKAI2 to bind signaling molecules, other than strigolactones or karrikins, and mediate their transduction.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Suberin plasticity to developmental and exogenous cues is regulated by a set of MYB transcription factors 95%
- The bacterial virulence factors rhamnolipids and their (R)-3-hydroxyalkanoate precursors activate Arabidopsis innate immunity through two independent mechanisms 95%
- Identification of RACK1A as a component of the auxin-ethylene crosstalk regulating apical hook development in Arabidopsis thaliana 95%
Similar papers in this journal
Similar papers in this journal
- Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain 95%
- Seed Longevity is Controlled by Metacaspases 95%
- A pair of readers of histone H3K4 methylation recruit Polycomb repressive complex 2 to regulate photoperiodic flowering 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.