The ERK5 MAP kinase regulates annexin complexes and membrane dynamics in embryonic stem cells
Brown, H. A.; Guillet, L.; Williams, C. A.; Shaw, H.; Zhou, H.; Rios-Szwed, D.; Fernandez-Alonso, R.; McMulkin, L.; Stavridis, M. P.; Findlay, G. M.
Show abstract
The ERK5 MAP kinase signalling pathway controls key processes in mouse Embryonic Stem Cells (mESCs) maintenance, including expression of naive pluripotency genes and a transcriptional programme for stem cell rejuvenation. However, quantitative proteomics suggests that ERK5 signalling controls levels of proteins implicated in diverse biological processes. Here, we show that Annexin A2 (ANXA2) and its accessory protein S100A10, which are implicated in regulation of membrane dynamics, are major targets of the ERK5 signalling pathway in mESCs. ERK5 activation promotes expression of the ANXA2/S100A10 protein complex via transcriptional induction of the KLF2 pluripotency factor. Furthermore, either ERK5 signalling or ectopic expression of the ANXA2/S100A10 complex promotes formation of membrane protrusions in mESCs. Our data therefore identify a new function for the ERK5 pathway in regulation of an Annexin complex and membrane dynamics, which may have implications for development and disease.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors 94%
- The transcription factor E2A drives neural differentiation in pluripotent cells 94%
- NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naive pluripotent stem cells 93%
Similar papers in this journal
- Y-complex nucleoporins independently contribute to nuclear pore assembly and gene regulation in neuronal progenitors 94%
- Primary myeloid cell proteomics and transcriptomics: importance of β tubulin isotypes for osteoclast function. 93%
- The Desmoglein 2 interactome in primary neonatal cardiomyocytes 93%
Similar papers in this journal
- The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program 95%
- PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking 94%
- Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.