Vaginal Microbiota Transplantation (VMT) for treatment of vaginal dysbiosis without the use of antibiotics: A Double-Blinded Randomized Controlled Trial in healthy women with vaginal dysbiosis

2024-07-01 obstetrics and gynecology Title + abstract only

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Here we describe the first double-blinded, randomized, placebo-controlled trial (RCT) on vaginal microbiota transplantation (VMT) without antibiotics in women with both symptomatic and asymptomatic vaginal dysbiosis. Forty-nine women were randomly assigned to VMT or placebo. The trial did not show a significant conversion to our predefined Lactobacillus-dominated microbiome. However, in participants not initially converting, antiseptic pretreatment before a subsequent VMT led to a 50% conversion...

Vaginal Microbiota Transplantation (VMT) for treatment of vaginal dysbiosis without the use of antibiotics: A Double-Blinded Randomized Controlled Trial in healthy women with vaginal dysbiosis

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