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Tumour-intrinsic features shape T-cell differentiation through myeloma disease evolution
2024-06-23
hematology
Title + abstract only
View on medRxiv
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The haematological malignancy multiple myeloma is associated with skewed T-cell activation and function. T-cell alterations are detectable in asymptomatic myeloma precursor conditions and have the potential to identify precursor patients at imminent risk of progression. However, what myeloma-associated T-cells alterations represent mechanistically, how they relate to tumour burden and gene expression, and what influences high inter-patient variability in immune composition remains unknown. Here,...
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