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Metabolic analysis in intact human-derived cerebral organoids by high-resolution magic-angle spinning NMR spectroscopy

Castilla Bolanos, M. A.; Chinchalongporn, V.; Ghosh Biswas, R.; Bailey, C.; Wu, M.; Soong, R.; Saleh, F.; Simpson, A.; Schuurmans, C.; Near, J.

2024-06-23 biophysics
10.1101/2024.06.21.599412 bioRxiv
Show abstract

Human-derived cerebral organoids (COs) are an emerging model system for the study of human neural development and physiology. Here, we describe the assessment of metabolism in human-derived COs using high-resolution magic-angle spinning (HR-MAS) NMR spectroscopy. Metabolic changes during development are assessed by studying COs at various stages of maturity. Our results suggest that COs exhibit a metabolic profile similar to in vivo human brain metabolism, albeit with a few notable metabolic differences.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.