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Shared genetic architecture and causal pathways between attention deficit hyperactivity disorder and restless legs syndrome
2024-06-21
psychiatry and clinical psychology
Title + abstract only
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Previous studies have revealed a significant overlap between ADHD and RLS populations, with shared pathological mechanisms such as dopaminergic function and iron metabolism deficits. However, the genetic mechanisms underlying these connections remain unclear. In our study, we conducted a genome-wide genetic correlation analysis to confirm a shared genetic structure between ADHD and RLS. We identified five pleiotropic loci through PLACO analysis, with colocalization analysis revealing a shared ca...
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