Anti-Neuraminidase Antibodies Reduce the Susceptibility to and Infectivity of Influenza A/H3N2 Virus
Hoy, G.; Cortier, T.; Maier, H. E.; Kuan, G.; Lopez, R.; Sanchez, N.; Ojeda, S.; Plazaola, M.; Stadlbauer, D.; Shotwell, A.; Balmaseda, A.; Krammer, F.; Cauchemez, S.; Gordon, A.
Show abstract
Immune responses against neuraminidase (NA) are of great interest for developing more robust influenza vaccines, but the role of anti-NA antibodies on influenza infectivity has not been established. We conducted household transmission studies in Managua, Nicaragua to examine the impact of anti-NA antibodies on influenza A/H3N2 susceptibility and infectivity. Analyzing these data with mathematical models capturing household transmission dynamics and their drivers, we estimated that having higher preexisting antibody levels against the hemagglutinin (HA) head, HA stalk, and NA was associated with reduced susceptibility to infection (relative susceptibility 0.67, 95% Credible Interval [CrI] 0.50-0.92 for HA head; 0.59, 95% CrI 0.42-0.82 for HA stalk; and 0.56, 95% CrI 0.40-0.77 for NA). Only anti-NA antibodies were associated with reduced infectivity (relative infectivity 0.36, 95% CrI 0.23-0.55). These benefits from anti-NA immunity were observed even among individuals with preexisting anti-HA immunity. These results suggest that influenza vaccines designed to elicit NA immunity in addition to hemagglutinin immunity may not only contribute to protection against infection but reduce infectivity of vaccinated individuals upon infection.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Characterizing the epidemiological interactions between influenza and respiratory syncytial viruses and their implications for epidemic control 95%
- Age-seroprevalence curves for the multi-strain structure of influenza A virus 95%
- Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases 94%
Similar papers in this journal
- SARS-CoV-2 infection-induced immunity and the duration of viral shedding: results from a Nicaraguan household cohort study 94%
- Detection of novel influenza viruses through community and healthcare testing: Implications for surveillance efforts in the United States 94%
- The role of viral interference in shaping RSV epidemics following the 2009 H1N1 influenza pandemic 93%
Similar papers in this journal
- Transient increased risk of influenza infection following RSV infection in South Africa; findings from the PHIRST study, South Africa, 2016-2018 96%
- Benefits of near-universal vaccination and treatment access to manage COVID-19 burden in the United States 94%
- Potential health and economic impact of paediatric vaccination using next generation influenza vaccines in Kenya: a modelling study 94%
Similar papers in this journal
- Differential recognition of computationally optimized H3 hemagglutinin influenza vaccine candidates by human antibodies 93%
- Characterization of SARS-CoV-2 intrahost genetic evolution in vaccinated and non-vaccinated patients from the Kenyan population 93%
- Optimizing the live attenuated influenza A vaccine backbone for high-risk patient groups 93%
Similar papers in this journal
- Effectiveness of Influenza Vaccines in the HIVE household cohort over 8 years: is there evidence of indirect protection? 95%
- The Nicaraguan Pediatric Influenza Cohort Study, 2011-2019: influenza incidence, seasonality, and transmission 94%
- BNT162b2 mRNA Vaccine Effectiveness Given Confirmed Exposure; Analysis of Household Members of COVID-19 Patients 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.