Using Galleria mellonella to study pathogen dissemination and anti-infective surface coatings.
Maslova, E.; Staber, C.; McCarthy, R. R.
Show abstract
Hospital associated infections and localised hospital outbreaks are a major challenge for infection control teams (ICTs) in hospitals around the world. Advances in artificial intelligence and infection modelling have enabled ICT teams to better predict and trace infection spread. However, it is notoriously difficult to replicate bacterial dissemination or validate prediction models in a laboratory setting due to a lack of effective in vivo models. In this work, we sought to develop Galleria mellonella as a model organism to replicate the dissemination of pathogens in a hospital intensive care unit (ICU). By combining this model organism with 3D printed models of a real hospital ICU, we are able to demonstrate that larvae do disseminate the multidrug resistant pathogen Acinetobacter baumannii within this ICU model and that it is possible to use this model to identify infection hotspots. Importantly, this model can also be used for intervention strategy testing as we also show that bacterial dissemination can be significantly mitigated by the introduction of antimicrobial wall surface coatings. This model provides a robust platform for the testing of antimicrobial surface coatings as well as the study of genetic determinants with a role in pathogen dissemination.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A comparison of several media types and basic techniques used to assess outdoor airborne fungi in Melbourne, Australia. 94%
- Evaluation of bacterial proliferation with a microfluidic-based device: Antibiochip. 94%
- Antimicrobial use in laboratory rodent facilities in Australia and New Zealand- a cross-sectional survey of veterinarians and facility managers 93%
Similar papers in this journal
- Real-world testing of the durability claims of a commercially available spray-on surface biocide 95%
- Laboratory evaluation of a quaternary ammonium compound (QAC)-based antimicrobial coating used in public transport during the COVID-19 pandemic 94%
- SimUrine: A Novel, Fully Defined Artificial Urinary Media for Enhanced Microbiological Research of Urinary Bacteria 93%
Similar papers in this journal
- Investigating the changing taxonomy and antimicrobial resistance of bacteria isolated from door handles in a new infectious disease ward pre- and post-patient admittance 94%
- Cultivating efficiency: High-throughput growth analysis of anaerobic bacteria in compact microplate readers. 93%
- Validation of selective agars for detection and quantification of Escherichia coli resistant to critically important antimicrobials 93%
Similar papers in this journal
- Stability of four carbapenem antibiotics in discs used for antimicrobial susceptibility testing 93%
- Evaluation of phenotypic and genotypic methods for the identification and characterisation of bacterial isolates recovered from catheter-associated urinary tract infections 92%
- Current and emerging polymyxin resistance diagnostics: a systematic review of established and novel detection methods 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.