Maternal Immunoglobulin A regulates the development of the neonatal microbiota and intestinal microbiota-specific CD4+ T cell responses
Abbott, D.; Rai, A. T.; Yang, A.; Cai, Y.; Fabre, S.; Frazer, A. J.; Deschepper, J. D.; Poholek, A. C.; Hand, T.
Show abstract
Breast milk is a complex mixture of nutrients and bioactives that promote infant development and decrease the incidence of chronic inflammatory disease. We investigated the role of one milk-derived bioactive, Immunoglobulin A (IgA) on the developing small intestinal microbiota and immune system. We demonstrate that early in life, milk-derived IgA suppressed colonization of the small intestine by Enterobacteriaceae and regulated the maturation of the small intestinal epithelium and the development of intestinal IL-17-producing CD4+ T cells. Enterobacteriaceae- specific CD4+ T cells, induced in the first weeks of life in the absence of milk-derived IgA, persisted in the intestine as memory T cells that can contribute to inflammatory disease later in life. Our study suggests that milk-derived IgA shapes mucosal immunity by regulating the neonatal microbiota thus preventing the development of long-lived intestinal microbiota-specific T cells.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism 96%
- Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5 95%
- Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity 95%