Mitochondrial Antiviral Pathways Control Anti-HIV Responses And Ischemic Stroke Outcomes Via The Rig-1 Signaling And Innate Immunity Mechanisms
Torices, S.; Moreno, T.; Ramaswamy, S.; Naranjo, O.; Teglas, T.; Osborne, O. M.; Park, M.; Sun, E.; Toborek, M.
Show abstract
Occludin (ocln) is one of the main regulatory cells of the blood-brain barrier (BBB). Ocln silencing resulted in alterations of the gene expression signatures of a variety of genes of the innate immunity system, including IFN-stimulated genes (ISGs) and the antiviral retinoic acid-inducible gene-1 (RIG-1) signaling pathway, which functions as a regulator of the cytoplasmic sensors upstream of the mitochondrial antiviral signaling protein (MAVS). Indeed, we observed dysfunctional mitochondrial bioenergetics, dynamics, and autophagy in our system. Alterations of mitochondrial bioenergetics and innate immune protection translated into worsened ischemic stroke outcomes in EcoHIV-infected ocln deficient mice. Overall, these results allow for a better understanding of the molecular mechanisms of viral infection in the brain and describe a previously unrecognized role of ocln as a key factor in the control of innate immune responses and mitochondrial dynamics, which affect cerebral vascular diseases such as ischemic stroke.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- ciRS-7 and miR7 regulate ischemia induced neuronal death via glutamatergic signaling 95%
- Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone 95%
- Hypoxia-inducible factor 1 protects neurons from Sarm1-mediated neurodegeneration 95%
Similar papers in this journal
- Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases 95%
- SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration 95%
- Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways 95%