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Dupilumab dampens mucosal type 2 response during acetylsalicylic acid challenge in N-ERD patients

2024-06-07 allergy and immunology Title + abstract only
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RationaleNon-steroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is characterized by the clinical triad of hypersensitivity to NSAIDs, nasal polyposis, and asthma. The cells and mediators causing acute symptoms when driving the hypersensitivity reaction to acetylsalicylic acid (ASA) ingestion, remain poorly defined. ObjectivesTo investigate the dynamics of nasal mediators during ASA provocation in N-ERD patients before and twenty-four weeks after therapy with the IL-4 recep...

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