Adipogenic differentiation and inflammatory response is orchestrated by regulating euchromatic histone methyltransferases.
Chakraborty, M.; Anirudhan, J.; Krishnamoorthy, V. K.; Shree, N.; Rampalli, S.
Show abstract
Euchromatic histone methyltransferases (EHMT1/2) play a key role in adipogenesis by regulating gene expression. While the downstream gene functions of EHMTs in adipogenic differentiation have been studied, their regulation and precise individual contributions remain elusive. We discovered the existence of a regulatory mechanism, wherein EHMT1 governs the interdependent expression of itself and the master regulator PPAR during the early phase of adipogenesis. In later stages, EHMT2 levels decline along with reduction in H3K9 dimethylation. Alteration of above sequence of events alone or in the presence of saturated-fatty acids lead to precocious induction of high levels of PPAR, accelerated adipogenesis and hypertrophic adipocytes with a pro-inflammatory phenotype. Countering the decrease in EHMTs effectively abrogated the inflammatory response of the adipocytes. Accordingly, induction of obesity by a high fat diet was sufficient to downregulate H3K9me2 levels and expression of EHMTs along with enhanced IL-6 generation. Taken together, our studies reveal a critical regulatory role played by EHMTs, which coordinates adipogenesis and obesity-induced inflammation.
Matching journals
The top 13 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- TRPV4 modulation affects mitochondrial parameters in adipocytes and its inhibition upregulates lipid accumulation 96%
- Manipulating mitochondrial dynamics in the NTS prevents diet-induced deficits in brown fat morphology and glucose uptake 93%
- Cannabinoid CB2 receptors enhance high-fat diet evoked peripheral neuroinflammation 92%
Similar papers in this journal
- In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds 95%
- Allicin regulates energy homeostasis through brown adipose tissue 94%
- Identification of a specific set of genes predicting obesity before phenotype appearance 93%
Similar papers in this journal
- Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3 96%
- Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning 96%
- Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue. 95%
Similar papers in this journal
- NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response 94%
- Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7 94%
- Creld2 function during unfolded protein response is essential for liver metabolism homeostasis 92%
Similar papers in this journal
- Hierarchical Regulation of Autophagy During Adipocyte Differentiation 95%
- Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation 95%
- The Gene Knockout of Angiotensin II Type 1a Receptor Improves High-fat Diet-Induced Obesity in rat via Promoting Adipose Lipolysis 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.