Motor cortex perineuronal net modulation improves motor function in a Parkinson's disease mouse model
Benacom, D.; Chataing, C.; Prochiantz, A.; Di Nardo, A. A.
Show abstract
The 6-OHDA mouse model recapitulates midbrain dopaminergic cell loss and associated motor deficits akin to those observed in Parkinsons disease. Emerging evidence suggests that modulating interneurons in the primary motor cortex could offer a means to mitigate symptoms. In the cortex, perineuronal nets (PNNs), a specialized extracellular matrix structure generally present around fast-spiking parvalbumin interneurons, can modulate neural activity and circuit plasticity. We found that removing PNNs through unilateral or bilateral ChABC injection in the motor cortex temporarily altered motor behavior. Surprisingly, bilateral reduced motor cortex PNNs are observed two weeks after unilateral 6-OHDA midbrain lesions, whereas five weeks after lesion, PNNs return to control levels. Subsequent bilateral ChABC injections significantly improved motor function in 6-OHDA animals only when associated with motor stimulation involving enriched housing and daily motor training. Thus, PNN modulation in the motor cortex of a Parkinsons disease model enables local circuits to adapt to the loss of dopaminergic inputs, resulting in improved motor behavior.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Nigral-specific increase in ser31 tyrosine hydroxylase phosphorylation offsets dopamine loss and forestalls hypokinesia onset during progressive nigrostriatal neuron loss 94%
- Moderate intensity aerobic exercise in 6-OHDA-lesioned rats alleviates established motor deficits and reduces neurofilament light and glial fibrillary acidic protein serum levels without increased striatal dopamine or tyrosine hydroxylase protein 94%
- Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration 93%
Similar papers in this journal
Similar papers in this journal
- Sensory responses in dorsolateral striatum are modulated by motor activity in a dopamine-dependent manner 95%
- Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice. 95%
- Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG 94%
Similar papers in this journal
Similar papers in this journal
- Chronic sodium bromide treatment relieves autistic-like behavioral deficits in three mouse models of autism 94%
- Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function 94%
- Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.