Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles
Park, D.; Fujise, K.; Wu, Y.; Lujan, R.; Del Olmo-Cabrera, S.; Wesseling, J.; De Camilli, P.
Show abstract
Members of the synaptophysin and synaptogyrin family are vesicle proteins with four transmembrane domains. In spite of their abundance in synaptic vesicle (SV) membranes, their role remains elusive and only mild defects at the cellular and organismal level are observed in mice lacking one or more family members. Here, we show that co-expression with synapsin of each of the four brain-enriched members of this family - synaptophysin, synaptoporin, synaptogyrin1 and synaptogyrin3 - in fibroblasts is sufficient to generate clusters of small vesicles in the same size range of SVs. Moreover, mice lacking all these four proteins have larger SVs. We conclude that synaptophysin and synaptogyrin family proteins play an overlapping function in the biogenesis of SVs and in determining their small size.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Neurotransmitter release is triggered by a calcium-induced rearrangement in the Synaptotagmin-1/SNARE complex primary interface 95%
- Peripheral Myelin Protein 22 Preferentially Partitions into Ordered Phase Membrane Domains 93%
- A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane 93%
Similar papers in this journal
- Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice. 93%
- Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2 93%
- Synapsin E-domain is essential for α-synuclein function 93%
Similar papers in this journal
Similar papers in this journal
- The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in mouse visual cortex 93%
- Centrosomal P4.1-associated protein (CPAP) is a novel regulator of ESCRT pathway function during endosome maturation 92%
- Prom1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.