Dorsal striatum involvement in response conflict management - A lesion study in rats
Poitreau, J.; Burle, B.; Sargolini, F.
Show abstract
Action control allows to respond to relevant stimuli while ignoring the non-relevant stimuli in the surrounding environment. In humans this process is generally studied in conflict tasks, such as the Simon task, in which participants respond with a left or right button press to the non-spatial relevant feature (e.g. the color) of a lateralized stimulus, while ignoring the stimulus position. In this study we used a visual version of the Simon task that we have previsously developed in rats to investigate the involvement of the dorsal striatum, a brain area that is central in action control processes. We tested the effect of excitotoxic lesions of the dorsomedial (DMS) and dorsolateral (DLS) areas in learning to control response interference. We showed that both DMS and DLS lesions negatively impacted rat performances, and this effect strongly depends on task practice. These results suggest an involvement of both areas in learning to manage response conflict.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Dissociating cholinergic influence on alertness andtemporal attention in primates in a simple reaction timeparadigm 95%
- Opportunities for risk-taking during play alters cognitive performance and prefrontal inhibitory signalling in rats of both sexes 95%
- Cholinergic interneurons in the dorsal striatum play an important role in the acquisition of duration memory 95%
Similar papers in this journal
- Delay-dependent cholinergic modulation of visual short-term memory in rhesus macaques 95%
- Effects of working memory training on cognitive flexibility, dendritic spine density and long-term potentiation in female mice 94%
- Deletion of the 5-HT3A receptor reduces behavioral persistence and enhances flexibility 93%
Similar papers in this journal
- Chemogenetic inhibition in the dorsal striatum reveals regional specificity of direct and indirect pathway control of action sequencing. 95%
- Medial prefrontal cortex and nucleus reuniens are critical for working memory in an operant delayed nonmatch task 95%
- The dorsal hippocampus' role in context-based timing in rodents 94%
Similar papers in this journal
- Mediodorsal thalamus is critical for updating during extra-dimensional shifts but not reversals in the attentional set-shifting task 97%
- Comparative roles of caudate and putamen in the serial order of behavior: Effects of striatal glutamate receptor blockade on variable versus fixed spatial self-ordered sequencing in marmosets 96%
- A common stay-on-goal mechanism in anterior cingulate cortex for information and effort choices 95%
Similar papers in this journal
- The hippocampus and dorso-lateral striatum link distinct types of memories through time and space, respectively 96%
- Dissociable contributions of basolateral amygdala and ventrolateral orbitofrontal cortex to flexible learning under uncertainty 95%
- Adolescent dopamine neurons represent reward differently during action and state guided learning 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.