Activation of the innate immune system accelerates growth in cooperation with oncogenic Ras
Brutscher, F.; Germani, F.; Hausmann, G.; Jutz, L.; Basler, K.
Show abstract
Innate immunity in Drosophila acts as an organismal surveillance system that measures external stimuli or cellular fitness and triggers context-specific responses to fight infections and maintain tissue homeostasis. However, uncontrolled activation of innate immune pathways can be detrimental to the system. In mammals, innate immune signaling is often overactivated in malignant cells and contributes to tumor progression. Drosophila tumor models have been instrumental in the discovery of interactions between pathways that promote tumorigenesis, but little is known about whether and how the Toll innate immune pathway interacts with oncogenes. Here we use a Drosophila epithelial in vivo model to investigate the interplay between Toll signaling and oncogenic Ras. In absence of oncogenic Ras, Toll signaling suppresses differentiation and induces apoptosis. In contrast, in the context of RasV12, cells are protected from cell death and Dorsal promotes cell survival and proliferation to drive hyperplasia. Taken together, we show that the tissue-protective functions of innate immune activity can be hijacked by pre-malignant cells to induce oncogenic transformation.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Flamingo participates in multiple models of cell competition 95%
- The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth 95%
- The role of Imp and Syp RBPs in precise neuronal elimination by apoptosis through the regulation of TFs 95%
Similar papers in this journal
- Drosophila fabp is a retinoid-inducible gene required for Rhodopsin-1 homeostasis and photoreceptor survival 96%
- Cell elimination strategies upon identity switch via modulation of apterous in Drosophila wing disc 95%
- α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain 95%
Similar papers in this journal
- Ataxin-2 is essential for neurodevelopment in Drosophila and is a major regulator of the cytoskeleton. 94%
- Drosophila RASopathy Models Identify Disease Subtype Differences and Biomarkers of Drug Efficacy 94%
- Novel newt regeneration genes regulate Wingless signaling to restore patterning in Drosophila eye 94%
Similar papers in this journal
- WNT Signalling Promotes NF-κB Activation and Drug Resistance in KRAS-Mutant Colorectal Cancer 95%
- Non-apoptotic caspase-dependent regulation of enteroblast quiescence in Drosophila 94%
- Non-apoptotic caspase activation sustains ovarian somatic stem cell functions by modulating Hedgehog-signalling and autophagy. 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.