A Human iPSC-derived Organoid System to Model Myelin Destruction and Repair
Ramesan, S.; Mason, J.; Swanson, M. E. V.; Mills, S.; Turner, B. J.; Rutar, M.; Gonsalvez, D. G.; Barton, S. K.
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We engineered a novel human iPSC-derived organoid system enriched with mature, myelinating oligodendrocytes and functionally reactive microglia. This model enables the study of human CNS remyelination following a demyelinating insult, encapsulating: myelin fragmentation, microglial clearance of myelin debris and oligodendrocyte genesis, differentiation, and axon ensheathment. This system provides a powerful and unparalleled capacity to interrogate complex human cell behaviour, relevant to those studying glial biology and neurological disease mechanisms.
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