Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis
Durham, L. E.; Humby, F.; Ng, N.; Gray, E. H.; Ryan, S. E.; Ross, R.; Povoleri, G. A. M.; Nuamah, R.; Fung, K.; Kallayil, A. M.; Dhami, P.; Kirkham, B. W.; Taams, L. S.
Show abstract
We hypothesised that skin and joint inflammation in psoriatic arthritis (PsA) is linked in terms of CD8+ T-cell phenotype and clonality. We employed scRNAseq to directly compare the transcriptional signature and T-cell receptor repertoire of memory T-cells from paired skin and synovial tissue and/or fluid from patients with PsA. We identified an enrichment of type-17 CD8+ tissue-resident memory (TRM) T-cells in both skin and joint, with a stronger IL-17 signature in the skin than the joint. Several T-cell clones were shared between the skin and joint and these shared clones tended to have the same signature at both sites, characterised by increased expression of genes associated with a cytotoxic, tissue-resident phenotype. Our findings support the hypothesis that skin and joint inflammation in PsA is linked in terms of T-cell clonality and raises the possibility that specific T-cells migrate between these compartments to propagate inflammation across both sites.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Single cell sequencing reveals expanded cytotoxic CD4+ T cells and two states of peripheral helper T cells in synovial fluid of ACPA+ RA patients 96%
- Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson Syndrome and Toxic epidermal necrolysis. 95%
- Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis 95%
Similar papers in this journal
- Distinct immune-effector and metabolic profile of CD8 + T Cells in patients with autoimmune polyarthritis induced by therapy with immune-checkpoint inhibitors 94%
- Ex vivo mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluid 94%
- Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis 93%
Similar papers in this journal
- Rewired type I IFN signaling is linked to age-dependent differences in COVID-19 94%
- Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type 1 interferon responses and distinct from other acute respiratory viruses 94%
- Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patients 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.