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Intracranial neurophysiological correlates of rumination

Chen, X.; Fan, Z.; Chen, D.; Wang, L.; Chen, L.; Yan, C.-G.

2024-05-09 neuroscience
10.1101/2024.05.08.593187 bioRxiv
Show abstract

Rumination is a transdiagnostic psychological process that plays a prominent role in many common psychiatric disorders, albeit its neurophysiological basis remains elusive. Existing neuroimaging studies have highlighted the precuneus and hippocampus as two essential brain regions in ruminations neural underpinnings. Here, we examined the intracranial electroencephalogram (iEEG) recordings from 21 patients with epilepsy during a naturalistic, continuous, active rumination state and measured the slow frequency (1-8 Hz) and high gamma (70-150 Hz) band oscillation powers. We observed enhanced slow frequency power in the precuneus and reduced high gamma power in the hippocampus during the rumination condition compared to the control condition. The hippocampal high gamma power reduction was associated with the self-reported reflection tendency. Our findings provided the first empirical evidence of the neurophysiological underpinnings of rumination and implicated a precuneus-hippocampus coupling across neural oscillation bands during an active rumination state.

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