Epigenenomic and transcriptomic characterization of NPM1-mutated CN-AML subtypes
NGuyen, L.; Tellez Quijorna, C.; Vernerey, J.; Garciaz, S.; Carbuccia, N.; Guille, A.; Burny, C.; Poplineau, M.; Murati, A.; Hospital, M. A.; Vey, N.; Birnbaum, D.; DUPREZ, E.
Show abstract
Cytogenetic normal AML with NPM1 mutations forms a distinct AML entity, associated with an intermediate prognosis and a heterogeneous response to treatment. We previously described an epigenetic biomarker, defined by the level of H3K27me3 on 70kb of the HIST1 cluster in patient blast DNA. This epigenetic mark separates cytogenetically normal NPM1mut AML into two groups of patients differing in their survival rate following chemotherapy. To better characterize the influence of the biomarker on disease progression, we performed transcriptomic and histone mark profiling on patient blasts according to the level of H3K27me3 HIST1. Our integrated analysis revealed that the two groups of patients display differences in terms of transcriptomic, chromatin landscape and cell surface markers, which could explain the clinical difference. Our profiling revealed novel targets and therefore constitutes an (epi)transcriptomic resource for NPM1 AML. It also highlights the power of epigenetic profiling to dissect the heterogeneity of a single AML genetic entity.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia 95%
- Adrenomedullin-CALCRL Axis Controls Relapse-Initiating Drug Tolerant Acute Myeloid Leukemia Cells 95%
- Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth 95%
Similar papers in this journal
- Complex genotype-phenotype relationships shape the response to treatment of Down Syndrome Childhood Acute Lymphoblastic Leukaemia 95%
- Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index 94%
- A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation 94%
Similar papers in this journal
- Mapping AML heterogeneity – multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses 97%
- AML/T cell interactomics uncover correlates of patient outcomes and the key role of ICAM1 in T cell killing of AML 95%
- Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal. 94%
Similar papers in this journal
- Whole Exome Sequencing and Single-Cell DNA Sequencing for Assessment of Clonal Heterogeneity and Evolution in Acute Myeloid Leukemia 94%
- A novel Boolean network inference strategy to model early hematopoiesis aging 92%
- A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system 91%
Similar papers in this journal
- Stable colony stimulating factor 1 fusion protein treatment increases HSC pool and enhances their mobilisation in mice. 92%
- CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia 92%
- First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.