Back

Cold adaptation in Upper Paleolithic hunter-gatherers of eastern Eurasia

Watanabe, Y.; Wakiyama, Y.; Waku, D.; Valverde, G.; Tanino, A.; Nakamura, Y.; Suzuki, T.; Koganebuchi, K.; Gakuhari, T.; Katsumura, T.; Ogawa, M.; Toyoda, A.; Mizushima, S.; Nagaoka, T.; Hirata, K.; Yoneda, M.; Nishimura, T.; Izuho, M.; Yamada, Y.; Masuyama, T.; Takahashi, R.; Ohashi, J.; NCBN Controls WGS Consortium, ; Oota, H.

2024-05-05 evolutionary biology
10.1101/2024.05.03.591810 bioRxiv
Show abstract

Previous genomic studies understanding the dispersal of Homo sapiens have suggested that present-day East Eurasians and Native Americans can trace their ancestry to migrations from Southeast Asia. However, ineluctable adaptations during the Last Glacial Maximum (LGM) remain unclear. By analyzing 42 genomes of up to 30-fold coverage from prehistoric hunter-gatherers, Jomon, we reveal their descent from Upper Paleolithic (UP) foragers who migrated to and isolated in the Japanese archipelago during Late Pleistocene. We provide compelling evidence suggesting that these UP people underwent positive selection for cold environments, aiding their survival through the LGM facilitated by non-shivering thermogenesis and detecting it polygenically across multiple loci in the Jomon lineage. Our study pioneers the close estimation of the physiological adaptation of ancient humans by the paleogenomic approach.

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

1
Science Advances
● 1243 papers in training set
Top 0.1%
26.8%
Similar papers in this journal
2
Science
● 477 papers in training set
Top 0.2%
22.1%
Similar papers in this journal
3
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 1.0%
18.7%
Similar papers in this journal
50% of probability mass above
4
eLife
● 5828 papers in training set
Top 19%
6.3%
Similar papers in this journal
5
Molecular Biology and Evolution
◐ 542 papers in training set
Top 1%
5.6%
Similar papers in this journal
6
Communications Biology
○ 993 papers in training set
Top 17%
1.4%
7
Nature Communications
○ 5641 papers in training set
Top 48%
1.3%
8
Journal of Genetics and Genomics
○ 38 papers in training set
Top 0.4%
1.1%
9
Genome Biology
○ 637 papers in training set
Top 7%
1.1%
10
PNAS Nexus
◐ 159 papers in training set
Top 2%
1.1%
11
Cell Genomics
○ 172 papers in training set
Top 3%
1.1%
12
iScience
○ 1154 papers in training set
Top 32%
1.0%
13
Genome Research
● 468 papers in training set
Top 6%
1.0%
14
National Science Review
◐ 21 papers in training set
Top 0.3%
0.9%
15
Nature Ecology & Evolution
131 papers in training set
Top 2%
0.9%
16
PLOS Genetics
● 862 papers in training set
Top 11%
0.9%
17
Current Biology
○ 665 papers in training set
Top 11%
0.6%
18
Genome Biology and Evolution
◐ 338 papers in training set
Top 3%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.