The COMT Val158Met Polymorphism is Significantly Associated with Early Onset Preeclampsia in Both African American and Caucasian Mothers.
Kaufman, M. R.; Hwang, A. E.; Pickrel, A. M.; Gray, C. M.; Goel, K. M.; Dhanraj, D. N.; Yaklic, J. L.; Maxwell, R. A.; Brown, T. L.
Show abstract
The aim of this study was to evaluate maternal and infant Val158Met polymorphisms of Catechol-O-Methyltransferase (COMT), a reported indicator of preeclamptic risk, in a United States population. Healthy control, early-onset preeclamptic, and late-onset preeclamptic patients were enrolled in this study. Genomic DNA was isolated from mothers and infants via buccal swabs and DNA was genotyped via tetra-primer amplification PCR. Our findings indicate that the COMT genotype was not significantly associated with late-onset PE. While there were no significant differences between African American and Caucasian races, the maternal COMTMet158Met genotype was significantly associated with early-onset preeclampsia in both African Americans and Caucasians when compared to COMTVal158Val or COMTVal158Met. These results suggest that the maternal COMTMet158Met genotype may be a risk factor for early-onset PE.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Prevalence, placenta development and perinatal outcomes of women with hypertensive disorders of pregnancy at Komfo Anokye Teaching Hospital 96%
- Prevalence and determinants of peripheral arterial disease in children with nephrotic syndrome 96%
- Coagulation abnormalities in children with uncorrected congenital heart defects seen at a teaching hospital in a developing country 95%
Similar papers in this journal
- Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia 93%
- Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gestational diabetes mellitus 92%
- Testosterone improves muscle function of the extensor digitorum longus in rats with sepsis 91%
Similar papers in this journal
- Decreased levels of soluble Developmental endothelial locus-1 are associated with thrombotic microangiopathy in pregnancy 96%
- Fetal exposure to endocrine disrupting-bisphenol A (BPA) alters testicular fatty acid metabolism in the adult offspring: relevance to sperm maturation and quality 93%
- From miRNA target gene network to miRNA function: miR-375 might regulate apoptosis and actin dynamics in the heart muscle via Rho-GTPases-dependent pathways 91%
Similar papers in this journal
- Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 infection severity 93%
- Transciptomic Analysis of the Effect of Remote Ischaemic Conditioning in an Animal Model of Necrotising Enterocolitis 92%
- Assessment of Gut Microbial β-Glucuronidase and β-Glucosidase Activity in Women with Polycystic Ovary Syndrome 92%
Similar papers in this journal
- Medroxyprogesterone reverses tolerable dose metformin-induced inhibition of invasion via matrix metallopeptidase-9 and transforming growth factor-β1 in KLE endometrial cancer cells 93%
- Polycystic ovary syndrome susceptibility loci inform disease etiological heterogeneity 92%
- Proton pump inhibitors use and risk of preeclampsia 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.