Characteristics of epitopes of limited variability on the head of influenza H1 haemagglutinin
Lourenco, J.; Zinad, H.; Kempton, J.; Gupta, S.
Show abstract
It is commonly assumed that naturally protective targets of immunity in influenza are highly variable. Theoretical work suggests, by contrast, that influenza evolution is primarily driven by naturally protective responses against epitopes of limited variability (ELV). At least one ELV has been identi[fi]ed on the head region of haemagglutinin of H1 influenza, opening up the possibility of producing a universal influenza vaccine. Here we demonstrate that the head region of H1 haemagglutinin can be decomposed into a number of discrete variable regions (VRs): ELVs tend to include a limited number of VRs compared to other epitopes either because of the smaller footprint of the associated antibody or because they are centred on VRs that are relatively isolated from others. We conclude that the variability of an antibody binding site is determined by the number of variable residues included in its footprint rather than the intrinsic entropy of any particular region.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Structure selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern 95%
- Characterization of changes in the hemagglutinin that accompanied the emergence of H3N2/1968 pandemic influenza viruses 95%
- Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination 93%
Similar papers in this journal
- Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations 95%
- Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans 94%
- Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70 94%
Similar papers in this journal
- Pox-AbDab: the Orthopoxvirus Antibody Database 94%
- Systematical assessment of the impact of single spike mutations of SARS-CoV-2 Omicron sub-variants on the neutralization capacity of post-vaccination sera 94%
- Immuno-informatics Study Identifies Conserved T Cell Epitopes in Non-structural Proteins of Bluetongue Virus Serotypes: Formulation of Computationally Optimized Next-Generation Broad-spectrum Multiepitope Vaccine 92%
Similar papers in this journal
- Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus 96%
- Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication 94%
- A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.