Time-resolved function of cell polarity kinases PRKCZ and PRKCI in CNS myelination
Mercau, M. E.; Hackbarth, R.-M.; Liu, X.; Wang, H.; Zhang, L.; Basu, M. K.; Rothlin, C. V.; Ghosh, S.
Show abstract
The atypical Protein Kinase C (aPKC) is a critical component of the PAR polarity complex, as well as of cell polarity in general. There are two paralogs of aPKC in the mammalian genome. Their expression pattern and functional role in oligodendrocyte lineage differentiation and development remains heretofore uncharacterized. Here we show that both paralogs of aPKC - PRKCI, the primary transcript of Prkci and PKMz, an alternate transcript of Prkcz - are expressed during oligodendrocyte differentiation, yet are functionally non-redundant. Asymmetric cell division and early specification of the oligodendrocyte fate stage required both paralogs. By contrast, the stage of oligodendrocyte maturation involving membrane polarization and myelination of axons continued to require PKMz, but no longer needed PRKCI. Taken together, our results indicate to a two-stage role of aPKCs and cell polarity in oligodendrocyte differentiation and development.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The npBAF to nBAF Chromatin Switch Regulates Cell Cycle Exit in the Developing Mammalian Cortex 96%
- Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence 96%
- Mouse Cortical Cellular Diversification Through Lineage Progression of Radial Glia 95%
Similar papers in this journal
- Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors 96%
- Differentiation signals from glia are fine-tuned to set neuronal numbers during development 96%
- Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation 96%
Similar papers in this journal
- A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro 96%
- Intrinsic microtubule destabilization of multiciliated choroid plexus epithelial cells during postnatal lifetime 95%
- In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.