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Accurate cross-platform GWAS analysis via two-stage imputation

2024-04-20 genetic and genomic medicine Title + abstract only
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In genome-wide association studies (GWAS), combining independent case-control cohorts has been successful in increasing power for meta and joint analyses. This success sparked interest in extending this strategy to GWAS of rare and common diseases using existing cases and external controls. However, heterogeneous genotyping data can cause spurious results. To harmonize data, we propose a new method, two-stage imputation (TSIM), where cohorts are imputed separately, merged on intersecting high-qu...

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