DNA virus infections shape transposable elements activity in vitro and in vivo
Tan, J.; Franke, V.; Neugebauer, E.; Pennisi, S.; Schaechtle, M. A.; Lagisquet, J.; Kuderna, A. K.; Walter, S.; Welker, I.; Ensser, A.; Landthaler, M.; Stamminger, T.; Gramberg, T.; Akalin, A.; Wyler, E.; Full, F.
Show abstract
Transposable elements (TEs) are implicated in a variety of processes including placental and preimplantation development and a variety of human diseases. TEs are known to be activated in the context of some viral infections, but the mechanisms and consequences are not understood. We show strong activation of TEs upon DNA virus infection, in particular the MLT- and THE1-class of LTR-containing retrotransposons as well as a subset of LINE-1-, Alu-elements and HERVs. Mechanistically, two key pathways induce TEs upregulation: inhibition of the KAP1/TRIM28 repressive complex by phosphorylation, and expression of the pioneer transcription factor double-homeobox 4 (DUX4), which is known to be involved in TE-induction during zygotic genome activation in embryonic development. DUX4 is induced by DNA viruses, it binds to TEs upon infection and analysis of genes adjacent to TEs shows pathways that are important for DNA virus infections. Analysis of knockdown, knockout and overexpression data reveal that almost all TEs expressed upon herpesviral infection are regulated by KAP1/TRIM28 and DUX4. Interestingly, analysis of single cell sequencing data from patients with DNA virus-associated cancers showed that in vivo TEs expression strongly correlates with virus infection, indicating a possible role in viral oncogenesis.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity 95%
- DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production 94%
- HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137 94%
Similar papers in this journal
- Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts 97%
- Caspases switch off m6A RNA modification pathway to reactivate a ubiquitous human tumor virus 96%
- Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes 95%
Similar papers in this journal
- Comprehensive genomic analysis reveals dynamic evolution of endogenous retroviruses that code for retroviral-like protein domains 95%
- Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells 93%
- SARS-CoV-2 infection activates endogenous retroviruses of the LTR69 subfamily 93%
Similar papers in this journal
- The HUSH epigenetic repressor complex silences PML nuclear bodies-associated HSV-1 quiescent genomes 96%
- Post-transcriptional regulation of human endogenous retroviruses by RNA-Binding Motif Protein 4, RBM4 96%
- Nuclear Speckles are Regulatory Hubs for Viral and Host mRNA Expression During HSV-1 Infection 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.